Our Team
Principle Investigator
Dr. Karine Leroch, Ph.D.
Karine Le Roch, Ph.D.
Assistant Professor
karine.leroch@ucr.edu
Phone: 951 827 5422
Fax: 951 827 3087
Dr. Le Roch received her BA. in 1995 from the University of Paris VI, France, where she majored in Biochemistry, Molecular Biology, Microbiology and Endocrinology.
Dr. Le Roch did an internship in a European exchange programme (Erasmus) in North Wales University, UK with Prof. M. Doenhoff where she worked on a larval stage protein of the human parasite, Schistosoma mansoni, a disease that affects more than 200 million people each year.
Dr. Le Roch obtained a master’s degree in Parasitology at the University of Lille II, France and the University of Oxford, U.K. in 1997. As a master’s student, She worked at the Institute of Molecular Medicine, John Radcliff Hospital, Oxford, UK with Dr. A. E. Wakefield. Her research focused on the genetic diversity of Pneumocystis carinii, a parasite infecting the lungs of immuno-suppressed patients.
She completed her Ph.D. in June 2001 at the University of Paris VI, France, under the supervision of Prof C. Deorig. Her research focused on the cell cycle regulation of the human malaria parasite, Plasmodium falciparum, and more specifically on cyclin dependant kinases to develop novel therapeutic approaches against the malaria parasite.
In 2001, as a postdoctoral fellow, she joined the Scripps Research Institute, San Diego, California and worked with Dr. E. Winzeler to set up the functional analysis of the P. falciparum genome using microarray technology. At that time, she worked in a close collaboration with the Genomics Institute of the Novartis Research Foundation (GNF, San Diego, California) to develop a new array technology for the screening of protease inhibitors in an effort to discover novel treatments. She joined GNF in January 2004 where she developed the malaria drug discovery program.
Since April 2006 at UCR, Dr. Le Roch research focuses on developing biological tools ex vivo to dissect the molecular events involved in the ubiquitin / proteasome pathway throughout the life cycle of P. falciparum. Using functional genomics approaches such as proteomics, She expect to elucidate critical regulatory networks driving the life cycle progression of the malaria parasite and identify novel drug targets against this devastating disease.
Lab Members
Research Assistants
Jacques Prudhomme
Email: jacques@ucr.edu
Phone: 951 827 5934
Biological Sciences Building Room 3210
Postdoctoral Fellows
Nadia Ponts, PhD
Email: nadia.ponts@ucr.edu
Phone: 951 827 5934
Graduate Students
Jianfeng (Jeff) Yang
Email: yangjianfeng@gmail.com
Bio: Currently I am a graduate student at CSE@UCR. I have a masters' degree from EE@THU and bachelors' degree from EE@USTC. My research interests include but are not limited to statistics, computation, information theory, AI, philosophy and their applications, especially in biology, economics, engineering and management. My hobbies are fishing, basketball, talking with my friends and thinking. Refer to my web site for more information.
Undergraduate Students
Eric McDaniel
Undergraduate of Biology & Biochemistry
Joseph Yacoub
Undergraduate of Neurobiology
Visiting Scholar
Randal Maile
Consultant and Webmaster
