M. Maduro Morris F. Maduro
Professor of Biology and Chair
Dept. of MCSB
Director, CMDB Grad Program
More info here.
G. Broitman-Maduro Gina Broitman- Maduro
Research Associate
Shruti Shruti Nemlekar
CMDB Major
RISE Summer 2003
Shahin Shahin Amani
Biology Major
Esmeralda Esmeralda Rivera
Biology Major
MARCU-STAR student
Akash Akash Verma
Biology Major
Previous Lab Members
We are looking for students to join our team! → More info here.

Structure and Evolution of Gene Regulatory Networks

Pristionchus, Gene Network, C. angaria embryos

Transcriptional Gene Regulatory Networks (GRNs) direct the development of multicellular animals, and are important in other contexts, including stem cell specification and development of cancer. Developmental GRNs typically exhibit layers of redundancy to assure the robust specification of early embryonic precursor cells. Changes in such networks are generally known to underlie differences in form and function between related species. Paradoxically, GRNs can also undergo evolutionary changes even when there is no apparent change in development, a phenomenon called Developmental System Drift. We have studied the specification of the embryonic endoderm precursor cell E in the nematode C. elegans and its close relatives for more than 20 years. In more distantly related species, the gene network for specifying the endoderm is simpler and has fewer factors, suggesting that the more complex network in C. elegans was derived from a simpler ancestral network. We are currently extending this work into nematodes of the genus Pristionchus. Our work promises to yield new insights into how gene networks evolve over time.

→ More information about our research here.


News Highlights
—  January, 2024 - NSF Grant Awarded!  —
NSF

We have been awarded a $1.3M grant from the National Science Foundation to study developmental system drift in endoderm specification, using Pristionchus.
NSF site: IOS#2341162 UCR Press Release

—  April 5, 2023 - Our paper on C. angaria was a finalist for Outstanding Paper  —
Seminar Announcement

Our 2022 paper on gut specification in C. angaria, a distant relative of C. elegans, was one of three finalists for from the journal Development.
Video on YouTube • Twitter/X link

→ See all news here.


Recent Papers

Broitman-Maduro G, Maduro M (2023). Evolutionary change in gut specification in Caenorhabditis centers on the GATA factor ELT-3 in an example of Developmental System Drift. J. Dev. Biol. 11, 32. https://doi.org/10.3390/jdb11030032 Abstract PDF

Broitman-Maduro G, Maduro M (2023). The long isoform of the C. elegans ELT-3 GATA factor can specify endoderm when overexpressed. microPublication Biology. https://doi.org/10.17912/micropub.biology.000748 Abstract PDF

Broitman-Maduro G, Sun S, Kikuchi T, Maduro M (2022). The ELT-3 GATA factor specifies endoderm in Caenorhabditis angaria in an ancestral gene network. Development (2022) 149 (21): dev200984. https://doi.org/10.1242/dev.200984 • Commented on in a Research Highlight. • UCR Press release here. • Finalist for Outstanding Paper of 2022 from Development (link). Abstract PDF

→ See all papers here.