Although MED-1 is a putative GATA factor, the DNA binding site, as determined by DNaseI footprinting of MED-1 with the promoters of its targets end-1 and end-3, is a non-canonical site containing the core sequence GTATAC. Pairs of these sites are found upstream of several genes expressed in the early E and MS lineages.
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MED-1 binding site based on footprinting of the end-1 and end-3 promoters
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