Recent Publications (of over 160)
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Michael C. Pirrung, Fa Zhang, Sudhakar Ambadi, and Y. Gangadhara Rao, “Total Synthesis of the Fellutamides, Lipopeptide Proteasome Inhibitors. More Sustainable Peptide Bond Formation,” J. Org. Chem., 80, 000 (2015). Link

Michael C. Pirrung, Goutam Biswas, Natalie De Howitt, and Jiayu Liao, “Synthesis and Bioluminescence of Difluoroluciferin,” Bioorg. Med. Chem. Lett., 24, 4881 (2014). Link

Michael C. Pirrung and Edwin M. Southern, “The Genesis of Microarrays,” Biochem. Mol. Biol. Ed., 42, 106 (2014). Link

Simmy Thomas, Natasha Sharma, Reyna Gonzalez, Peng-Wen Pao, Florence M. Hofman, Thomas C. Chen, Stan G. Louie, Michael C. Pirrung, and Axel H. Schönthal, “Repositioning of Verrucosidin, a Purported Inhibitor of Chaperone Protein GRP78, as an Inhibitor of Mitochondrial Electron Transport Chain Complex I,” PLOS One, 8, e65695 (2013). Link

Michael C. Pirrung and Jenifer N. Nalbandian, “Catalyzed Claisen Rearrangements of O-Allyl Kojates,” Tetrahedron Lett., 54, 3752 (2013). Link

John Opoku-Ansah, Tannya R. Ibarra-Rivera, Michael C. Pirrung, and André S. Bachmann, “Syringolin B-inspired Proteasome Inhibitor Analogue TIR-203 Exhibits Enhanced Biological Activity in Multiple Myeloma and Neuroblastoma,” Pharm. Biol., 50, 25 (2012). Link

Yongfeng Zhao, Michael C. Pirrung, and Jiayu Liao, “A Fluorescent Amino Acid Probe to Monitor Efficiency of Peptide Conjugation to Glass Surfaces for High Density Microarrays,” Mol. Biosyst., 8, 879 (2012). Link

Michael C. Pirrung, Fa Zhang, Sudhakar Ambadi, and Tannya R. Ibarra-Rivera, “Reactive Esters in Amide Ligation with b-Hydroxyamines,” Eur. J. Org. Chem., 4283 (2012). Link

Tannya R. Ibarra-Rivera, John Opoku-Ansah, Sudhakar Ambadi, André S. Bachmann, and Michael C. Pirrung, “Synthesis and Cytotoxicity of Syringolin B-Based Proteasome Inhibitors,” Tetrahedron, 67, 9950 (2011). Link

Ashish Anshu, Simmy Thomas, Puneet Agarwal, Tannya R. Ibarra-Rivera, Michael C. Pirrung, Axel H. Schönthal, “Novel Proteasome-Inhibitory Syrbactin Analogs That Trigger Endoplasmic Reticulum Stress and Induce Apoptosis in Hematological Tumor Cell Lines,” Biochem. Pharmacol. 82, 600 (2011). Link

Michael C. Pirrung, Timothy M. Dore, Vipul S. Rana, and Yue Zhu, “Sensitized Two-photon Photochemical Deprotection,” Chem. Commun., 5313 (2010). Link

Michael C. Pirrung, Goutam Biswas, and Tannya R. Ibarra-Rivera, “Total Synthesis of Syringolin A and B,” Org. Lett., 12, 2402 (2010). Link

Michael C. Pirrung, Biswajit G. Roy, and Surendra Gadamsetty, “Structure-Reactivity Relationships in (2-Hydroxyethyl)benzophenone Photoremovable Protecting Groups,” Tetrahedron, 66, 3147 (2010). Link

Marci Surpin, Yunfan Zou, Chiyi Xiong, Natasha V. Raikhel, and Michael C. Pirrung, “Iodine Scanning of a Phenazine Inhibitor of Vacuolar Sorting,” Bioorg. Med. Chem. Lett., 20, 1496 (2010). Link

Michael C. Pirrung and Jianmei Wang, ”Multicomponent Reactions of Cyclobutanones,” J. Org. Chem., 74, 2958 (2009). Link

Michael C. Pirrung, Subir Ghorai, and Tannya R. Ibarra-Rivera, “Multicomponent Reactions of Convertible Isonitriles,” J. Org. Chem., 74, 4110 (2009).Link

Nicholas J. G. Webster and Michael C. Pirrung, “Small Molecule Activators of the Trk Receptors for Neuroprotection,” BMC Neurosci., 9 (Suppl. 2), S1 (2008). Link

Michael C. Pirrung, Koushik Das Sarma and Jianmei Wang, “Hydrophobicity and Mixing Effects on Select Heterogeneous, Water-Accelerated Synthetic Reactions,” J. Org. Chem., 73, 8723 (2008). Link

Michael C. Pirrung, Anthony B. Bleecker, Yoshihisa Inoue, Fernando Rodríguez, Norimitsu Sugawara, Takehiko Wada, Yunfan Zou, and Brad M. Binder, ”Ethylene Receptor Antagonists: Strained Alkenes Are Necessary But Not Sufficient,” Chem. Biol., 15, 313 (2008). Link

Yunfan Zou, Marcela Rojas-Pierce, Natasha V. Raikhel, and Michael C. Pirrung, ”Preparation of Methyl Ester Precursors of Biologically Active Agents,” BioTechniques, 44, 377 (2008). Link

Xin Xiong and Michael C. Pirrung, ”Modular Synthesis of Candidate Indole-based Insulin Mimics by Claisen Rearrangement,” Org. Lett., 10, 1151 (2008). Link

Michael C. Pirrung, Liu Deng, Bo Lin, and Nicholas J. G. Webster, ”Quinone Replacements for Small Molecule Insulin Mimics,” Chembiochem, 9, 360 (2008). Link

Bo Lin, Zhitao Li, Kaapjoo Park, Liu Deng, Ashok Pai, Ling Zhong, Michael C. Pirrung, and Nicholas J. G. Webster, “Identification of Novel Orally-available Small Molecule Insulin Mimics,” J. Pharmacol. Exp. Ther., 323, 579 (2007). Link

Xin Xiong and Michael C. Pirrung, ”Practical Synthesis of 7-Prenylindole,” J. Org. Chem., 72, 5832 (2007). Link

Hyunsoo Kim, Liu Deng, Xin Xiong, William Hunter, Melissa Long, and Michael C. Pirrung, “Glyceraldehyde-3-phosphate Dehydrogenase is a Cellular Target of Demethylasterriquinone B1”, J. Med. Chem., 50, 3423 (2007). Link

Michael C. Pirrung, Zhitao Li, Yufa Liu, Erika Hensley, Aparna Tanksale, Bo Lin, Ashok Pai, and Nicholas J. G. Webster, ”Parallel Synthesis of Indolylquinones and Their Cell-based Insulin Mimicry,” J. Comb. Chem., 9, 844 (2007). Link

Bo Lin, Michael C. Pirrung, Liu Deng, Zhitao Li, Yufa Liu, and Nicholas J. G. Webster, “Neuroprotection by Small Molecule Activators of the NGF Receptor,” J. Pharmacol. Exp. Ther., 322, 59 (2007). Link

Michael C. Pirrung and Subir Ghorai, “Versatile, Fragrant, Convertible Isonitriles,” J. Am. Chem. Soc., 128, 11772 (2006).Link

Khisimuzi E. Mdluli, Pamela R. Witte, Toni Kline, Adam W. Barb, Alice L. Erwin, Bryce E. Mansfield, Amanda L. McClerren, Michael C. Pirrung, L. Nathan Tumey, Paul Warrener, Christian R. H. Raetz, and C. Kendall Stover, ”Molecular validation of LpxC as an antibacterial drug target in Pseudomonas aeruginosa,”Antimicrob. Agents Chemother. 50, 2178 (2006).Link

Michael C. Pirrung and Koushik Das Sarma, “Aqueous Medium Effects on Multi-component Reactions,” Tetrahedron, 61, 11456 (2005).Link

Michael C. Pirrung, Sunil V. Pansare, Koushik Das Sarma, Kathy A. Keith, and Earl R. Kern, “Combinatorial Optimization of Isatin-beta-Thiosemicarbazones as Anti-Poxvirus Agents,” J. Med. Chem., 48, 3045 (2005).Link

Michael C. Pirrung, Yufa Liu, Liu Deng, Diana K. Halstead, Zhitao Li, John F. May, Michael Wedel, Darrell A. Austin, and Nicholas J. G. Webster, ”Methyl Scanning: Total Syntheses of Demethylasterriquinone B1 and Derivatives for Identification of Sites of Interaction with and Isolation of Its Receptors,” J. Am. Chem. Soc., 127, 4609 (2005).Link

The ENCODE Project Consortium, “The ENCODE (ENCyclopedia of DNA Elements) Project,” Science, 306, 636-640 (2004).Link





















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