Michael C. Pirrung, Michael Wedel, and Yan Zhao, “7-Alkyl Indole Synthesis via a Convenient Formation/Alkylation of Lithionitrobenzenes and an Improved Bartoli Reaction,“ Synlett, 143 (2002).

Michael C. Pirrung, Hao Liu, and Andrew T. Morehead, Jr., “Rhodium Chemzymes: Michaelis-Menten Kinetics in Dirhodium(II) Carboxylate-Catalyzed Carbenoid Reactions,“ J. Am. Chem. Soc., 124, 1014 (2002).

Michael C. Pirrung, “How to Make a DNA Chip,“Angew. Chem., Int. Ed., 41, 1276 (2002).

Hyunsoo Kim and Michael C. Pirrung, “Arrayed Primer Extension Computing with Variant mRNA Splice Forms. Multiple Isoforms of CD44 in a Human Breast Tumor,” J. Am. Chem. Soc., 124, 4934 (2002).

John H. Reif, Thomas H. LaBean, Michael Pirrung, Vipul S. Rana, Bo Guo, Carl Kingsford, and Gene S. Wickham, “Experimental Construction of Very Large Scale DNA Databases with Associative Search Capability,” Jonoska, N., Seeman, N. C., Eds., DNA Computing (DNA7), Lecture Notes in Computer Science 2340, Springer, Heidelberg, 2002, p. 231.

Michael C. Pirrung, Kaapjoo Park, and L. Nathan Tumey, “19F Encoded Combinatorial Libraries: Discovery of Selective Metal-binding and Catalytic Peptoids,” J. Comb. Chem., 4, 329 (2002).

Michael C. Pirrung, Zhitao Li, Kaapjoo Park, and Jin Zhu, “Total Syntheses of Demethylasterriquinone B1, an Orally Active Insulin Mimetic, and Demethylasterriquinone A1,“ J. Org. Chem., 67, 7919 (2002).

Michael C. Pirrung, L. Nathan Tumey, Christian R. H. Raetz, Jane E. Jackman, Karnem Snehalatha, Amanda L. McClerren, Carol A. Fierke, Stephanie L. Gantt, and Kristin Rusche, “Inhibition of the Antibacterial Target UDP-(3-O-acyl)-N-acetylglucosamine Deacetylase (LpxC). Isoxazoline Zinc Amidase Inhibitors Bearing Diverse Metal Binding Groups,” J. Med. Chem., 45, 4359 (2002).

Michael C. Pirrung, Liu Deng, Zhitao Li, and Kaapjoo Park, “Synthesis of 2,5-Dihydroxy-3-(indol-3-yl)-benzoquinones by Acid-catalyzed Condensation,” J. Org. Chem., 67, 8374 (2002).

Michael C. Pirrung, L. Nathan Tumey, Amanda L. McClerren, and Christian R. H. Raetz, “High-Throughput Catch-and-Release Synthesis of Oxazoline Hydroxamates. Structure-activity Relationships of Novel Inhibitors of E. coli LpxC. in vitro Enzyme Inhibition and Antibacterial Properties,” J. Am. Chem. Soc., 125, 1575 (2003).

Nicholas J. G. Webster, Kaapjoo Park, and Michael C. Pirrung, “Signaling Effects of Demethylasterriquinone B1: a Selective Insulin Receptor Modulator (SIRM),” ChemBioChem, 4, 379 (2003).

Michael C. Pirrung and Hao Liu, “Parallel Synthesis and Screening of an Illudinoid Combinatorial Library,” Org. Lett., 6, 1983 (2003).

Jungsan Sohn, Brendan Kiburz, Zhitao Li, Liu Deng, Alexias Safi, Michael C. Pirrung, and Johannes Rudolph, “Inhibition of Cdc25 Phosphatases by Indolyldihydroxy-quinones,” J. Med. Chem., 46, 2580 (2003).

Michael C. Pirrung, Wolfgang Pieper, Krishna P. Kaliappan, and M. R. Dhananjeyan, "Combinatorial Discovery of Two-photon Photoremovable Protecting Groups," Proc. Natl. Acad. Sci. USA., 100, 12548 (2003).

Michael C. Pirrung and Koushik Das Sarma, “Multi-component Reactions Are Accelerated in Water,” J. Am. Chem. Soc., 126, 444 (2004).

Lyudmila Yakovleva, Christopher J. Handy, Jane M. Sayer, Michael Pirrung, Donald M. Jerina, and Stewart Shuman, “Benzo[c]phenanthrene Adducts and Nogalamycin Inhibit DNA Transesterification by Vaccinia Topoisomerase,” J. Biol. Chem., 279, 23335 (2004).

Michael C. Pirrung and Koushik Das Sarma, “beta-Lactam Synthesis by Ugi Reaction of beta-Ketoacids in Aqueous Solution,” Synlett, 1425 (2004).

The ENCODE Project Consortium, “The ENCODE (ENCyclopedia of DNA Elements) Project,” Science, 306, 636-640 (2004).

Michael C. Pirrung, Koichi Fujita, and Kaapjoo Park, “Organometallic Routes to 2,5-Dihydroxy-3-(indol-3-yl)-benzoquinones. Synthesis of Demethylasterriquinone B4,” J. Org. Chem., 70, 2537 (2005).

Michael C. Pirrung and Vipul S. Rana, “Photoremovable Protecting Groups in DNA Synthesis and Microarray Fabrication,” in "Dynamic Studies in Biology: Phototriggers, Photoswitches, and Caged Compounds,” Goeldner M. and Givens, R. S., Eds., Wiley, NY, 2005, p. 341-368.

Michael C. Pirrung, Yufa Liu, Liu Deng, Diana K. Halstead, Zhitao Li, John F. May, Michael Wedel, Darrell A. Austin, and Nicholas J. G. Webster, ”Methyl Scanning: Total Syntheses of Demethylasterriquinone B1 and Derivatives for Identification of Sites of Interaction with and Isolation of Its Receptors,” J. Am. Chem. Soc., 127, 4609 (2005).

Michael C. Pirrung, Zhitao Li, and Hao Liu, “Synthetic Libraries of Fungal Natural Products,” in "Combinatorial Synthesis of Natural Product Based Libraries,” Boldi., A. M., Ed., CRC Press, NY, 2005.

Michael C. Pirrung, Sunil V. Pansare, Koushik Das Sarma, Kathy A. Keith, and Earl R. Kern, “Combinatorial Optimization of Isatin-beta-Thiosemicarbazones as Anti-Poxvirus Agents,” J. Med. Chem., 48, 3045 (2005).

Michael C. Pirrung and Koushik Das Sarma, “Aqueous Medium Effects on Multi-component Reactions,” Tetrahedron, 61, 11456 (2005).

Khisimuzi E. Mdluli, Pamela R. Witte, Toni Kline, Adam W. Barb, Alice L. Erwin, Bryce E. Mansfield, Amanda L. McClerren, Michael C. Pirrung, L. Nathan Tumey, Paul Warrener, Christian R. H. Raetz, and C. Kendall Stover, ”Molecular validation of LpxC as an antibacterial drug target in Pseudomonas aeruginosa,”Antimicrob. Agents Chemother. 50, 2178 (2006).

Michael C. Pirrung and Subir Ghorai, “Versatile, Fragrant, Convertible Isonitriles,” J. Am. Chem. Soc., 128, 11772 (2006).

Bo Lin, Michael C. Pirrung, Liu Deng, Zhitao Li, Yufa Liu, and Nicholas J. G. Webster, “Neuroprotection by Small Molecule Activators of the NGF Receptor,” J. Pharmacol. Exp. Ther., 322, 59 (2007). Link

Michael C. Pirrung, Zhitao Li, Yufa Liu, Erika Hensley, Aparna Tanksale, Bo Lin, Ashok Pai, and Nicholas J. G. Webster, ”Parallel Synthesis of Indolylquinones and Their Cell-based Insulin Mimicry,” J. Comb. Chem., 9, 844 (2007). Link

Hyunsoo Kim, Liu Deng, Xin Xiong, William Hunter, Melissa Long, and Michael C. Pirrung, “Glyceraldehyde-3-phosphate Dehydrogenase is a Cellular Target of Demethylasterriquinone B1”, J. Med. Chem., 50, 3423 (2007). Link

Xin Xiong and Michael C. Pirrung, ”Practical Synthesis of 7-Prenylindole,” J. Org. Chem., 72, 5832 (2007). Link

Bo Lin, Zhitao Li, Kaapjoo Park, Liu Deng, Ashok Pai, Ling Zhong, Michael C. Pirrung, and Nicholas J. G. Webster, “Identification of Novel Orally-available Small Molecule Insulin Mimics,” J. Pharmacol. Exp. Ther., 323, 579 (2007). Link

Michael C. Pirrung, Liu Deng, Bo Lin, and Nicholas J. G. Webster, ”Quinone Replacements for Small Molecule Insulin Mimics,” Chembiochem, 9, 360 (2008). Link

Xin Xiong and Michael C. Pirrung, ”Modular Synthesis of Candidate Indole-based Insulin Mimics by Claisen Rearrangement,” Org. Lett., 10, 1151 (2008). Link

Yunfan Zou, Marcela Rojas-Pierce, Natasha V. Raikhel, and Michael C. Pirrung, ”Preparation of Methyl Ester Precursors of Biologically Active Agents,” BioTechniques, 44, 377 (2008). Link

Michael C. Pirrung, Anthony B. Bleecker, Yoshihisa Inoue, Fernando Rodríguez, Norimitsu Sugawara, Takehiko Wada, Yunfan Zou, and Brad M. Binder, ”Ethylene Receptor Antagonists: Strained Alkenes Are Necessary But Not Sufficient,” Chem. Biol., 15, 313 (2008). Link

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